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Morphine is a pain medication of the opiate family that is found naturally in a dark brown, resinous form, from the poppy plant (Papaver somniferum). It can be taken orally or injected; it is also often smoked.^[7][9] It acts directly on the central nervous system (CNS) to increase feelings of pleasure and warm relaxation and reduce pain, and is often abused for this purpose.^[7] It can be taken for both acute pain and chronic pain and is frequently used for pain from myocardial infarction, kidney stones, and during labor.^[7] Morphine can be administered by mouth, by injection into a muscle, by injection under the skin, intravenously, injection into the space around the spinal cord, or rectally.^[7] Its maximum effect is reached after about 20 minutes when administered intravenously and 60 minutes when administered by mouth, while the duration of its effect is 3–7 hours.^[7][8] Long-acting formulations of morphine are available as MS-Contin, Kadian, and other brand names as well as generically.

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Potentially serious side effects of morphine include decreased respiratory effort, vomiting, nausea, and low blood pressure.^[7] Morphine is addictive and prone to abuse.^[7] If one’s dose is reduced after long-term use, opioid withdrawal symptoms may occur.^[7] Common side effects of morphine include drowsiness, vomiting, and constipation.^[7] Caution is advised for use of morphine during pregnancy or breast feeding, as it may affect the health of the baby.^[7][2]

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Morphine was first isolated between 1803 and 1805 by German pharmacist Friedrich Sertürner.^[10] This is generally believed to be the first isolation of an active ingredient from a plant.^[11] Merck began marketing it commercially in 1827.^[10] Morphine was more widely used after the invention of the hypodermic syringe in 1853–1855.^[10][12] Sertürner originally named the substance morphium, after the Greek god of dreams, Morpheus, as it has a tendency to cause sleep.^[12][13]

The primary source of morphine is isolation from poppy straw of the opium poppy.^[14] In 2013, approximately 523 tons of morphine were produced.^[15] Approximately 45 tons were used directly for pain, a four-fold increase over the last twenty years.^[15] Most use for this purpose was in the developed world.^[15] About 70 percent of morphine is used to make other opioids such as hydromorphone, oxymorphone, and heroin.^[15][16][17] It is a Schedule II drug in the United States,^[16] Class A in the United Kingdom,^[18] and Schedule I in Canada.^[19] It is also on the World Health Organization’s List of Essential Medicines.^[20] Morphine is sold under many trade names.^[1] In 2018, it was the 132nd most commonly prescribed medication in the United States, with more than 5 million prescriptions.

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